The high density of large mammals in the Dzanga Sangha rainforest has produced a type of landscape that is favourable to a large diversity of mammals, and in a wider sense to a wealth of flora and fauna. Thus for example, forest buffalos are dependant on clearings created by elephants, in order to find adequate forage. The giant forest hog and the bongo equally favour these clearings.
The following mammals have been identified in the Reserve:
| Order Primates |
| Pan troglodytes Chimpanzee |
| Gorilla gorilla Gorilla |
| Piliocolobus oustaleti (Colobus pennanti oustaleti) Central African red colobus |
| Colobus guereza |
| Papio anubis Olive Baboon |
| Cercocebus agilis (Cercocebus galeritus agilis) Agile Mangabey |
| Lophocebus albigena (Cercocebus albigena) Grey-cheeked Mangabey |
| Cercopithecus neglectus De Brazza's Monkey |
| Cercopithecus pogonias (Cercopithecus mona pogonias) Crowned Guenon |
| Cercopithecus nictitans Große Putty-nosed Monkey |
| Cercopithecus cephus Moustached Monkey |
| Perodicticus potto Bosman's Potto |
| Euoticus elegantulus Western Needle-clawed |
| Galago alleni Allen's Galago |
| Galago senegalensis Senegal Galago |
| Galagoides demidof (Galagoides demidovii) Demidoff's Galago |
| Order Chiroptera |
| Insectivorous - Order Insectivora |
| Potamogale velox Giant Otter-Shrew |
| Atelerix albiventris East African Hedgehog |
| Suncus remyi |
| Sylvisorex sp. |
| Sylvisorex pluvialis |
| Sylvisorex ollula |
| Sylvisorex johnstoni |
| Paracrocidura schoutedeni |
| Crocidura sp. |
| Crocidura batesi |
| Crocidura denti |
| Crocidura dolichura |
| Crocidura goliath |
| Crocidura hildegardeae |
| Crocidura ludia |
| Crocidura mutesae |
| Crocidura nigrofusca |
| Crocidura olivieri |
| Order Macroscelidea - Macroscélides |
| Petrodromus tetradactylus Four-toed or forest elephant-Shrew |
| Order Rodentia - Rodent |
| Myosciurus pumilio Dwarf Squirrel |
| Funisciurus lemniscatus Four-striped tree Squirrel |
| Funisciurus pyrrhopus Red-footed tree Squirrel |
| Funisciurus leucogenys |
| Funisciurus isabella Gray |
| Heliosciurus gambianus Gambia Sculptor Squirrel |
| Heliosciurus rufobrachium Red-legged sun Squirrel |
| Paraxerus poensis |
| Protoxerus stangeri Giant forest Squirrel |
| Anomalurus derbianus Lord Derby's flying Squirrel |
| Anomalurus pusillus Dwarf scaly-tailed Squirrel |
| Anomalurus beecrofti Beecroft's Scaly-tailed Squirrel |
| Idiurus zenkeri Pygmy Scaly-tailed flying Squirrel |
| Zenkerella insignis Cameroon scaly-tail |
| Graphiurus sp. |
| Atherurus africanus Brush-tailed Porcupine |
| Thryonomys sp. Marsh Cane Rat sp. |
| Deomys ferrugineus |
| Cricetomys emini Giant Rat |
| Lophuromys nudicaudus |
| Malacomys longipes nudicaudus |
| Praomys jacksoni |
| Praomys tullbergi |
| Hylomyscus aeta |
| Hylomyscus alleni |
| Heimyscus fumosus |
| Mus minutoides |
| Mus setulosus |
| Grammomys rutilans |
| Stochomys longicaudatus |
| Oenomys hypoxanthus |
| Hybomys univittatus |
| Lemniscomys striatus |
| Rattus sp. |
| Order Carnivora - Carvorous |
| Mellivora capensis Honey Badger |
| Aonyx congica Congo Clawless Otter |
| Lutra maculicollis Spotted-necked Otter |
| Herpestes naso Long-snouted Mongoose |
| Atilax paludinosus Marsh Mongoose |
| Bdeogale nigripes Black-footed Mongoose |
| Genetta tigrina Large spotted Genet |
| Genetta servalina Servaline Genet |
| Genetta victoriae Giant Genet |
| Civettictis civetta (Viverra civetta) African Civet |
| Nandinia binotata African Palm Civet |
| Felis aurata Golden Cat |
| Panthera pardus Leopard |
| Order Pholidota - Pholidota |
| Uromanis tetradactyla (Manis tetradactyla) Long-tailed Pangolin |
| Phataginus tricuspis (Manis tricuspis) Tree Pangolin |
| Smutsia gigantea (Manis gigantea) Giant Pangolin |
| Order Tubulidentata - Tubulidentata |
| Orycteropus afer Aardvark |
| Dendrohyrax dorsalis (Dendrohyrax arboreus) |
| Hyracoidea |
| Dendrohyrax dorsalis (Dendrohyrax arboreus) |
| Order Proboscidea |
| Loxodonta africana cyclotis |
| Order Artiodactyla |
| Hippopotamus amphibius Hippopotamus |
| Potamochoerus porcus Red River Hog |
| Hylochoerus meinertzhageni Western Giant Hog |
| Hyemoschus aquaticus Water Chevrotain |
| Syncerus caffer African Buffalo |
| Tragelaphus scriptus Bushbuck |
| Tragelaphus euryceros (Boocercus euryceros) Bongo |
| Tragelaphus spekei Sitatunga |
| Cephalophus monticola Blue Duiker |
| Cephalophus nigrifrons Black-fronted Duiker |
| Cephalophus leucogaster White-bellied Duiker |
| Cephalophus callipygus Peters Duiker |
| Cephalophus silvicultor Yellow-backed Duiker |
| Cephalophus dorsalis Bay Duiker, black band Duiker |
| Neotragus batesi Dwarf Antelope |